Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice.
Premkumar K, Pachiappan A, Abraham SK, Santhiya ST, Gopinath PM, Ramesh A.
Department of Genetics, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India.
Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg(-1), p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.
PUB: Fitoterapia. 2001 Dec;72(8):906-11.
Clastogenic effects of dietary supplement--Spirulina alga, and some medicinal plant products from Boswellia serrata, Withania somnifera on mice.
Ghoshal S, Mukhopadhyay MJ, Mukherjee A.
Centre of Advanced Study in Cell and Chromosome Research, Department of Botany, University of Calcutta, Kolkata, India.
Pretreatment of aqueous extracts of Zyrulina (Spirulina), Aswagandha (Withania) and Nopane (Boswellia) on colchicine induced chromosome damage showed weakness of clastogenic activity in Swiss albino mice. None of the treatments increased significantly the number of chromosome aberrations.
PUB: Indian J Exp Biol. 2001 Oct;39(10):1068-70.
Protective effect of Spirulina fusiformis on chemical-induced genotoxicity in mice.
Premkumar K, Abraham SK, Santhiya ST, Ramesh A.
Department of Genetics, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India.
Spirulina fusiformis given by oral route to mice at doses of 250, 500 and 1000 mg kg(-1) significantly inhibit the genotoxicity induced by cisplatin and urethane. In addition, a significant reduction in the extent of lipid peroxidation with concomitant increase in the liver enzymatic (GPx, GST, SOD, CAT) and non-enzymatic (reduced glutathione) antioxidants were observed.
PUB: Fitoterapia. 2004 Jan;75(1):24-31.
