Effect of supplementation of blue green alga (Spirulina) on outcome of pregnancy in rats.
Kapoor R, Mehta U.
Department of Foods and Nutrition, Haryana Agricultural University, Hisar, India.
To study the supplementary effect of Spirulina, pregnant rats were fed 5 different kinds of diets (casein, Spirulina, wheat gluten, Spirulina + wheat gluten, Spirulina-without additional vitamins and minerals), each providing 22% protein during the period of pregnancy. The outcome of pregnancy was assessed from litter and dams' weight and litter size. Maternal weight gain was found to be maximum with Spirulina + wheat gluten and least with the wheat gluten diet. Rats receiving Spirulina containing diets produced significantly (p < 0.05) higher litter size than those receiving casein and wheat gluten. In spite of having higher litter size, Spirulina containing diet groups produced pups with birth weights comparable to those of casein. Spirulina appears to be a good dietary supplement during pregnancy.
PUB: Plant Foods Hum Nutr. 1993 Jan;43(1):29-35.
Supplementary effect of spirulina on hematological status of rats during pregnancy and lactation.
Kapoor R, Mehta U.
Department of Home Science, Sri Sathya Sai Institute of Higher Learning Anantapur, Andhra Pradesh, India.
The effect of Spirulina on iron status was assessed based on hemoglobin, packed cell volume, serum iron, total iron binding capacity and ferritin levels of rats during pregnancy and lactation. Rats were fed 5 different kinds of diets (casein, Spirulina, wheat gluten, Spirulina + wheat gluten, Spirulina without additional vitamins and minerals) each providing 22 percent protein. Diets containing Spirulina alone or in combination with wheat gluten resulted in significantly higher iron storage and hemoglobin contents than casein and wheat gluten diets during the first half of pregnancy and lactation. Wheat gluten diet result in the smallest increase in hemoglobin levels and iron stores compared to other diets. The values of serum iron and iron binding capacity remained unchanged with different diets. Spirulina appears to be effective in improving the iron status of rats during pregnancy and lactation.
PUB: Plant Foods Hum Nutr. 1998;52(4):315-24.
Teratogenic study of Spirulina in mice
Chamorro G, Salazar M.
Escuela Nacional de Ciencias Biologicas Instituto Politecnico Nacional (IPN) Mexico D.F., Mexico.
The embryotoxic and fetotoxic potential of Spirulina was investigated in mice. The algae was given to pregnant animals at the levels of 0, 10, 20 and 30 g/100 in the diet through days 7-13, 1-13 and 1-19 of gestation. On day 19, the rats were sacrificed, and the uterine horns were examined for live, dead and resorbed fetuses. The live fetuses were weighed and examined for external malformations and either skeletal or visceral abnormalities. With the litter as the unit of analysis and when the total number of fetuses affected was considered, no significant difference was found in the number of resorbed or malformed among groups. These results indicate that the feeding of pregnant mice with algae, up to a dietary level of 30 g/100, did not evoke any signs of embryotoxic effects. The Spirulina levels tested in this study represent exaggeration over any anticipated human consumption.
PUB: Arch Latinoam Nutr. 1990 Mar;40(1):86-94.
